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ABCB1 Gene Is Associated With Clinical Response to SNRIs in a Local Chinese Han Population

Xiao-Xiao Shan1,2, Yan Qiu1,2, Wei-Wei Xie3

  • 1Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Pharmacology
|July 24, 2019
PubMed

Insights

The ATP-binding cassette subfamily B member 1 (ABCB1) gene showed no association with selective serotonin reuptake inhibitor (SSRI) treatment response in major depressive disorder (MDD) patients. However, the ABCB1 rs2032583 polymorphism may predict improved response to serotonin-norepinephrine reuptake inhibitors (SNRIs).

Area of Science:

  • Pharmacogenetics
  • Neuroscience
  • Genetics

Background:

  • The ATP-binding cassette subfamily B member 1 (ABCB1) gene has been implicated in major depressive disorder (MDD).
  • Previous studies in Chinese Han populations suggest associations between specific ABCB1 single-nucleotide polymorphisms (SNPs) and MDD, though findings vary.
  • Understanding the role of ABCB1 in treatment response is crucial for personalized medicine in MDD.

Purpose of the Study:

  • To investigate the association between ABCB1 gene polymorphisms and therapeutic responses to selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
  • To explore the predictive value of ABCB1 SNPs for treatment outcomes in a Chinese Han population with MDD.

Main Methods:

  • A cohort of 292 MDD patients was recruited from a local Chinese Han population.
  • Patients were treated with either SSRIs or SNRIs and assessed weekly for six weeks using the 17-item Hamilton Rating Scale for Depression (HAM-D17).
  • Genotyping of six ABCB1 SNPs was performed, and their distribution was compared between treatment responders and non-responders.

Main Results:

  • No significant differences in genotype or allele distribution of the six studied ABCB1 SNPs were found between responders and non-responders in the SSRI therapy group.
  • In the SNRI therapy group, the ABCB1 rs2032583 polymorphism was significantly associated with therapeutic response.
  • Logistic regression analysis indicated that the C allele of ABCB1 rs2032583 was negatively correlated with treatment response to SNRIs, suggesting the TT genotype may predict better outcomes.

Conclusions:

  • ABCB1 gene polymorphisms do not appear to be associated with therapeutic responses to SSRIs in this MDD cohort.
  • The rs2032583 polymorphism in the ABCB1 gene may serve as a predictive factor for improved treatment response to SNRIs among Chinese patients with MDD.
  • Further validation in larger, diverse patient cohorts is recommended to confirm these findings.

Keywords:
ABCB1 geneSNRIsclinical responselocal Chinese Han populationmajor depressive disorder

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