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Updated: Jan 21, 2026

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

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Oxidation State Dependent Conformational Changes of HMGB1 Regulate the Formation of the CXCL12/HMGB1 Heterocomplex

Enrico M A Fassi1, Jacopo Sgrignani1, Gianluca D'Agostino1

  • 1Institute for Research in Biomedicine, Università della Svizzera Italiana, CH-6500 Bellinzona, Switzerland.

Computational and Structural Biotechnology Journal
|July 24, 2019
PubMed

Keywords:
CXCL12CXCL12, C-X-C motif chemokine 12CXCR4, C-X-C chemokine receptor type 4Conformational ensembleHMGB1HMGB1, High-mobility Group Box 1MD, Molecular dynamicsMolecular dynamicsProtein-protein dockingRMSD, Root mean square deviationRoG, Radius of gyrationSASA, Solvent accessible surface areaTLR2 or TLR4, Toll-like Receptor 2 or 4ds-HMGB1, Disulfide High-mobility Group Box 1fr-HMGB1, Full reduced High-mobility Group Box 1

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