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Reduction of yellow fever virus mouse neurovirulence by immunization with a bacterially synthesized non-structural
1London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, St Albans, Hertfordshire, U.K.
The Journal of General Virology
|June 1, 1988
Abstract:
Part of a yellow fever virus-specified non-structural protein (NS1) was expressed in Escherichia coli as a fusion protein with beta-galactosidase. Immunization of mice with this partially purified NS1-beta-galactosidase fusion protein induced yellow fever virus-specific antibodies and provided some protection against intracerebral challenge with the virus.