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Updated: Jan 21, 2026

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
Published on: May 31, 2024
An Exceptionally Potent Inhibitor of Human CD73
Christine E Bowman1, Rafael G da Silva2, Amber Pham1
1Department of Quantitative Biology , Arcus Biosciences, Inc. , 3928 Point Eden Way , Hayward , California 94545 , United States.
Abstract:
We recently reported the initiation of a Phase I clinical trial with AB680, a potent human CD73 inhibitor, being developed for the treatment of solid tumors (NCT03677973). We undertook a detailed kinetic analysis of the interaction between human CD73 and AB680 to determine the mode of inhibition. We found AB680 to be a reversible, slow-onset competitive inhibitor of human CD73 with a Ki of 5 pM. Clinical candidates of this potency are uncommon and deserve special consideration during lead optimization.
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