Related Experiment Video
Updated: Jan 21, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
The prognostic roles of cyclooxygenase-2 for patients with basal cell carcinoma
1a Department of Oncology, Chuiyangliu Hospital affiliated to Tsinghua University , Beijing , China.
Abstract:
Background: Cyclooxygenase-2 (Cox-2) is critical for tumor invasion, angiogenesis, and poor prognosis in many human cancers. It was reported to be an abnormal expression in many human malignancies, including basal cell carcinoma (BCC). However, the prognostic significance of cox-2 in BCC was still unclear. The aim of this study was to investigate the prognostic roles of cox-2 for patients with BCC. Methods: We detected the expression of cox-2 both at mRNA and protein level in tumor tissue and adjacent normal tissues from 180 patients with BCC by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis, respectively. Results: Cox-2 expression was significantly increased in BCC tissues compared with the adjacent normal cohorts (p < .001). Its expression was significantly associated with angiogenesis (p < .001) and depth of invasion (p < .001). Kaplan-Meier analysis suggested patients with high expression of cox-2 had a shorter overall survival rate than those with low expression (log rank test, p < .001). Conclusions: The expression of cox-2 was up-regulated in BCC and it could be used as a bio-marker for the prognosis of BCC patients with a high risk of recurrence.
Related Concept Videos
Role of Myosin in Cell Migration
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
Laminins are the Adhesive Proteins of Basal Lamina
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
Basal Lamina are the Specialized Form of ECM
Proteins...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can...
Role of Microtubules in Cell Wall Deposition
The Role of Actin and Myosin in Non-muscle Cells

