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Future Approaches to Precision Oncology-Based Clinical Trials
Arjun Mittra1, Jeffrey A Moscow2
1From the Developmental Therapeutics Clinic.
Cancer Journal (Sudbury, Mass.)
|July 24, 2019
Summary
Precision oncology has advanced cancer therapy, necessitating new clinical trial designs beyond traditional phases. The next two decades will focus on evolving precision oncology trials through innovation and infrastructure changes.
Area of Science:
- Oncology
- Precision Medicine
- Clinical Trial Design
Background:
- Precision oncology has rapidly advanced cancer treatment over the past 20 years.
- The shift from traditional chemotherapy to targeted therapies requires a reevaluation of clinical trial methodologies.
Purpose of the Study:
- To discuss the evolution of precision oncology clinical trials.
- To outline the necessary changes in trial design and implementation for individualized cancer care.
Main Methods:
- Conceptual analysis of the paradigm shift in cancer therapy.
- Forecasting future trends in precision oncology clinical trials.
Main Results:
- The prevailing model of cancer therapy is now precision oncology.
- Traditional phase I to III clinical trial structures are becoming outdated.
Conclusions:
- Fundamental changes in oncology clinical trial design and implementation are essential.
- The next 20 years will see significant evolution in precision oncology trials driven by scientific, technological, and regulatory advancements.
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