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Related Concept Videos

What are Cells?01:07

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
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What are Cells?01:15

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
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Hair Cells01:22

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Chemistry of the Cell02:58

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The cell is chemically composed of water, organic molecules and inorganic ions.
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Related Experiment Video

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In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
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In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

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Cutaneous B-Cell Lymphoblastic Lymphoma.

Dilru Amarasekera1, Deirdre Connolly2, Ashley Gochoco2

  • 1Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.

The American Journal of Dermatopathology
|July 24, 2019
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Summary

B-cell lymphoblastic lymphoma (B-LBL) is a rare cancer. This case highlights simultaneous skin and systemic B-LBL, emphasizing key diagnostic markers like CD79a, Tdt, and CD10.

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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • B-cell lymphoblastic lymphoma (B-LBL) is a rare subtype of lymphoblastic lymphoma, typically affecting immature B cells.
  • While most commonly presenting with bone lesions, B-LBL can rarely manifest cutaneously.

Observation:

  • A case of simultaneous cutaneous and systemic B-LBL in a 28-year-old male is presented.
  • The lymphoblastic infiltrate showed positivity for CD79a, Tdt, CD10, and CD20.
  • Diagnosis confirmed widespread skin, bone, and lymph node involvement.

Findings:

  • A review of cutaneous B-LBL cases indicates CD79a (92.3%), Tdt (90.6%), and CD10 (83.3%) are the most frequent positive tumor markers.
  • Nearly half of all cutaneous B-LBL cases present with systemic involvement.

Implications:

  • This case underscores the importance of considering cutaneous B-LBL in differential diagnoses, even with systemic involvement.
  • Accurate identification of tumor markers is crucial for diagnosing and managing B-LBL.
  • Further research into rare presentations of B-LBL can improve diagnostic strategies and patient outcomes.