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Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor CAR T Cell Infusions in Mice
Published on: February 24, 2023
Preventive infusion of donor-derived CAR-T cells after haploidentical transplantation: Two cases report
Cheng Zhang1, Ying-Ying Ma1, Jun Liu1
1Department of Hematology, Xinqiao Hospital, Army Medical University; State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing.
Rationale:
Relapse is the main cause of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, there are no efficient methods to prevent relapse after allo-HSCT. Chimeric antigen receptor T (CAR-T) cells have achieved favorable outcomes in the treatment of refractory/relapsed acute lymphoblastic leukemia (ALL) because of their strong anti-leukemia activity. However, it is unclear whether the CAR-T cells constructed using viral systems can be used as preventive infusions to prevent relapse after haploidentical HSCT.
Patient Concerns:
Two patients with ALL with high risk received haploidentical HSCT.
Diagnoses:
Two patients were diagnosed with ALL with high risk.
Interventions:
Patients received preventive infusion of donor-derived CAR-T cells constructed using viral systems on day 60 after haploidentical HSCT.
Outcomes:
The CAR-T cells were continually detected, and no graft versus host disease developed. The two patients survived with disease-free for 1 year and 6 months, respectively.
Lessons:
Preventive infusion of donor-derived CAR-T cells after haploidentical HSCT may be safe and that immunosuppressors may not affect the proliferation of CAR-T cells.
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