Pediatric heart transplantation in the current era

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Optimization of the Cuff Technique for Murine Heart Transplantation
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Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

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Laura D'Addese1, Anna Joong2, Michael Burch1

  • 1Cardiology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK.

Current Opinion in Pediatrics
|July 24, 2019
PubMed

Insights

Pediatric heart transplantation (PHTx) outcomes are improving with strategies like ABO incompatible listing. However, international practice variations persist in PHTx management and immunosuppression.

Area of Science:

  • Pediatric Cardiology
  • Transplantation Medicine
  • Immunology

Background:

  • Pediatric heart transplantation (PHTx) is a critical treatment for end-stage congenital heart disease and cardiomyopathy.
  • Graft survival in PHTx recipients has significantly improved, ranging from 13 to 22 years.

Purpose of the Study:

  • To offer an international perspective on the current state of pediatric heart transplantation.
  • To review recent advancements and ongoing challenges in PHTx.

Main Methods:

  • Review of international registry data and collaborative initiatives.
  • Analysis of multicenter studies on PHTx management and outcomes.

Main Results:

  • Waitlist survival and long-term outcomes in PHTx are progressively improving.
  • Strategies to expand the donor pool include ABO incompatible listing and wider weight ranges.
  • Significant international variations exist in listing, donor acceptance, immunosuppression, surveillance, and retransplantation practices.

Conclusions:

  • Despite improvements, international practice variations in pediatric heart transplantation require standardization.
  • Ongoing research and collaborative efforts are essential for advancing PHTx knowledge and patient care.
  • Common morbidities such as infection, rejection, and renal dysfunction necessitate continued monitoring and management strategies.
Abstract

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