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Optimization of the Cuff Technique for Murine Heart Transplantation
Published on: June 26, 2020
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Pediatric heart transplantation in the current era
Laura D'Addese1, Anna Joong2, Michael Burch1
1Cardiology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Current Opinion in Pediatrics
|July 24, 2019
Summary
Pediatric heart transplantation (PHTx) outcomes are improving with strategies like ABO incompatible listing. However, international practice variations persist in PHTx management and immunosuppression.
Area of Science:
- Pediatric Cardiology
- Transplantation Medicine
- Immunology
Background:
- Pediatric heart transplantation (PHTx) is a critical treatment for end-stage congenital heart disease and cardiomyopathy.
- Graft survival in PHTx recipients has significantly improved, ranging from 13 to 22 years.
Purpose of the Study:
- To offer an international perspective on the current state of pediatric heart transplantation.
- To review recent advancements and ongoing challenges in PHTx.
Main Methods:
- Review of international registry data and collaborative initiatives.
- Analysis of multicenter studies on PHTx management and outcomes.
Main Results:
- Waitlist survival and long-term outcomes in PHTx are progressively improving.
- Strategies to expand the donor pool include ABO incompatible listing and wider weight ranges.
- Significant international variations exist in listing, donor acceptance, immunosuppression, surveillance, and retransplantation practices.
Conclusions:
- Despite improvements, international practice variations in pediatric heart transplantation require standardization.
- Ongoing research and collaborative efforts are essential for advancing PHTx knowledge and patient care.
- Common morbidities such as infection, rejection, and renal dysfunction necessitate continued monitoring and management strategies.
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