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The subdivision behavior of polymeric tablets.

Marcilio Cunha-Filho1, Maíra T Teixeira1, Víctor Santos-Rosales2

  • 1Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasília (UnB), 70910-900 Brasília, DF, Brazil.

International Journal of Pharmaceutics
|July 24, 2019
PubMed
Summary

Soluplus® (SOL) polymeric tablets demonstrate superior subdivision performance compared to polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) tablets. Post-treatments further enhance SOL tablet properties, offering improved tablet subdivision for pharmaceutical applications.

Keywords:
FriabilityHot-melt extrusionMass lossMass variationPolymeric tabletsTablet subdivision

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Polymer Science

Background:

  • Tablet subdivision is crucial for accurate pharmaceutical dosing.
  • Evaluating polymeric matrices for improved tablet subdivision is essential.
  • Soluplus® (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA), and hydroxypropyl methylcellulose (HPMC) are common pharmaceutical polymers.

Purpose of the Study:

  • To assess the subdivision behavior of polymeric tablets made with SOL, PVPVA, and HPMC.
  • To investigate the impact of post-treatments (aging, thermal, CO2) on tablet properties.
  • To determine the key factors for successful tablet subdivision.

Main Methods:

  • Preparation of polymeric tablets using SOL, PVPVA, and HPMC.
  • Application of various post-treatments to the tablets.
  • Assessment of mechanical properties (e.g., mass variation, friability).
  • Spectroscopic and microstructural analysis.

Main Results:

  • SOL tablets exhibited significantly lower mean mass variation (3.9%) compared to PVPVA (7.2%) and HPMC (9.1%) tablets.
  • Post-treatments reduced mass loss and friability in SOL tablets to near zero without altering porosity.
  • Thermal treatment improved PVPVA tablet subdivision, while HPMC tablets showed compaction issues.
  • Uniform internal structure and mechanical strength are vital for tablet subdivision.

Conclusions:

  • Soluplus® (SOL) is a promising polymer for developing tablets with excellent subdivision characteristics.
  • Post-treatments can significantly enhance the subdivision properties of certain polymeric tablets.
  • Tablet formulation and processing must consider mechanical strength and internal structure for effective subdivision.