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Toll-like receptor 2 expression on monocytes and microvascular complications in type 2 diabetic patients

Rasha Emad Badr1, Mona Ibrahim Salama1, Asmaa Kamal Abd-Elmaogood2

  • 1Lecturer of Clinical and Chemical Pathology Department, Faculty of Medicine, Portsaid University, Portsaid, Egypt.

Diabetes & Metabolic Syndrome
|July 25, 2019
PubMed

Insights

Toll-like receptor 2 (TLR2) is overexpressed in Egyptian patients with type 2 diabetes, particularly those with complications. This finding links TLR2 to diabetes progression and associated vascular issues.

Area of Science:

  • Immunology
  • Endocrinology
  • Cardiovascular Research

Background:

  • Diabetes mellitus (DM) is a chronic illness where atherosclerotic changes are often overlooked.
  • Toll-like receptor 2 (TLR2) is implicated in atherosclerosis progression, with potential malfunctions in diabetic patients' monocytes.

Purpose of the Study:

  • To assess the association between TLR2 and type 2 diabetes mellitus (T2DM) in Egyptian patients.
  • To investigate the relationship between TLR2 and diabetic complications.

Main Methods:

  • The study included 60 diabetic patients (complicated and non-complicated) and 30 healthy controls.
  • Mean fluorescent intensity (MFI) of TLR2 was measured using flow cytometry.

Main Results:

  • TLR2 expression was significantly associated with T2DM.
  • Elevated TLR2 MFI was observed in complicated diabetic patients compared to non-complicated diabetics and healthy controls.
  • A significant correlation was found between TLR2 MFI and random blood sugar (RBS) and glycated hemoglobin (HbA1c).

Conclusions:

  • TLR2 is overexpressed in diabetic patients with microvascular complications.
  • This overexpression suggests a role for TLR2 in the development or progression of diabetic complications.
Keywords:
Diabetes mellitusMean fluorescent intensityRandom blood sugarToll-like receptor 2

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