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Augmentation of IL-6 production contributes to development of gestational diabetes mellitus: An Indian study
Samreen Siddiqui1, Swati Waghdhare2, Chhavi Goel3
1Institute of Endocrinology, Diabetes & Metabolism, Max Healthcare Inst. Ltd, Saket, New Delhi, 110017, India; Amity Institute of Virology & Immunology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, 201313, India.
Aim:
Inflammatory mediators like interleukin-6 (IL-6) and acute phase protein like C-reactive protein (CRP) are supposed to contribute to development of GDM, however clinical data supporting this hypothesis is limited. This study was designed to analyze the association of IL-6 and CRP with development of GDM in Indian females.
Methods:
This case control study included pregnant women diagnosed as GDM (n = 53) and those having normal glucose tolerance (n = 50). Serum levels of IL-6 and CRP were analysed and correlated with various clinical parameters.
Results:
Serum IL-6 levels were significantly high (p < 0.05) in GDM females as compared to control females. IL-6 levels correlated with pre-pregnancy body mass index (BMI), fasting blood sugar (FBS) and postprandial sugar (PPBS). Unlike IL-6, CRP levels did not show significant differences between GDM and control females. However, positive correlation of CRP levels with BMI, FBS and PPBS was observed.
Conclusion:
High IL-6 levels in gestational diabetes may indicate a possible role for inflammation in pathophysiology of GDM.
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