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The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders
Airi Jo-Watanabe1, Toshiaki Okuno1, Takehiko Yokomizo2
1Department of Biochemistry, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Abstract:
Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various allergic diseases, including asthma (neutrophilic asthma and aspirin-sensitive asthma), allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and anaphylaxis. This review summarizes the biology of LTs and their receptors, recent developments in the area of anti-LT strategies (in settings such as ongoing clinical studies), and prospects for future therapeutic applications.
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