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Delayed gastric emptying in rx-negative dyspepsia.

D L Dumitraşcu1, S Cotul, S Tamaş

  • 1Institute of Hygiene and Public Health, Cluj-Napoca, Romania.

Physiologie (Bucarest)
|January 1, 1988
PubMed
Summary

Delayed gastric emptying was identified in most patients with upper digestive dyspepsia using a radioisotopic test. This finding suggests prokinetic drugs may help manage symptoms of functional gastrointestinal disorders.

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Area of Science:

  • Gastroenterology
  • Nuclear Medicine

Background:

  • Upper digestive dyspepsia presents with symptoms like pyrosis, nausea, and bloating.
  • Conventional roentgenological findings are often negative in these cases, complicating diagnosis.

Purpose of the Study:

  • To investigate the utility of a radioisotopic test in detecting delayed gastric emptying in patients with upper digestive dyspepsia.
  • To assess the role of gastric emptying time in the pathophysiology of functional dyspepsia.

Main Methods:

  • A radioisotopic test using a 500 ml saline meal labeled with 113m In-DTPA was administered.
  • Gastric emptying was monitored sequentially using a gammacamera linked to a microcomputer.
  • The half-time of gastric emptying was calculated and compared to normal values (8-25 min).

Main Results:

  • Delayed gastric emptying was detected in 9 out of 11 subjects (82%) presenting with upper digestive dyspepsia.
  • The radioisotopic method provided quantitative assessment of gastric emptying in patients with negative roentgenological findings.

Conclusions:

  • Delayed gastric emptying is a significant finding in a majority of patients with functional upper digestive dyspepsia.
  • Prokinetic drug therapy should be considered for managing symptoms associated with delayed gastric emptying in functional gastrointestinal disorders.

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