Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Environmental variables differentially affect ethanol-stimulated activity in selectively bred mouse lines.

J C Crabbe1, C M Deutsch, B R Tam

  • 1Research Service, VA Medical Center Portland, OR 97201.

Psychopharmacology
|January 1, 1988
PubMed
Summary

Selective breeding for ethanol (EtOH) response in mice revealed environmental factors significantly influence results. Bright light and EtOH exposure order, not just genetics, impact mouse activity levels, crucial for behavioral research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents.

International review of neurobiology·2016
Same author

Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication.

Genes, brain, and behavior·2016
Same author

Nest building is a novel method for indexing severity of alcohol withdrawal in mice.

Behavioural brain research·2016
Same author

Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication.

Genes, brain, and behavior·2015
Same author

Resection of subsequent pulmonary metastases from treated head and neck squamous cell carcinoma: systematic review and meta-analysis.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2014
Same author

Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice.

Genes, brain, and behavior·2013

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Pharmacology

Background:

  • Selective breeding aims to create mouse lines with high (FAST) and low (SLOW) responses to ethanol (EtOH).
  • Observed divergence between FAST and SLOW lines has plateaued despite continued selection.
  • Previous research suggests environmental factors like light and injection order influence EtOH response.

Purpose of the Study:

  • To investigate the influence of environmental factors on EtOH-induced activity in selectively bred mice.
  • To confirm and extend findings on the effects of light intensity and injection order on EtOH response.
  • To optimize experimental conditions for differentiating FAST and SLOW mouse lines.

Main Methods:

  • Experiments utilized selectively bred FAST and SLOW mice, alongside non-selected Swiss mice.

Related Experiment Videos

  • Mice were tested under varying light conditions (bright vs. dim) and injection orders (EtOH-Saline vs. Saline-EtOH).
  • Behavioral activity was measured in an open field test following EtOH administration.

    • Main Results:

    • Environmental factors confirmed to influence EtOH response magnitude, consistent with prior studies.
    • The difference between FAST and SLOW mice was amplified under bright light conditions.
    • A greater line difference was observed when mice were initially tested with EtOH (EtOH-Saline order).

    Conclusions:

    • Environmental conditions significantly modulate ethanol's behavioral effects in mice.
    • Optimizing light and injection order can enhance the differentiation between genetic lines selected for EtOH response.
    • These findings are critical for refining experimental designs in alcohol research and behavioral genetics.