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Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
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Fibroblast Growth Factor Receptor Functions in Glioblastoma

Ana Jimenez-Pascual1, Florian A Siebzehnrubl2

  • 1European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff CF24 4HQ, UK.

Cells
|July 25, 2019
PubMed

Insights

Fibroblast growth factor receptors (FGFRs) play a key role in glioblastoma progression. This review covers FGFR functions and therapeutic strategies targeting FGFRs in brain cancer.

Area of Science:

  • Neuro-oncology
  • Cancer biology
  • Molecular signaling

Background:

  • Glioblastoma is a lethal adult brain cancer with significant genetic heterogeneity.
  • Aberrant receptor tyrosine kinase signaling is common in glioblastoma.
  • Fibroblast growth factor receptors (FGFRs) signaling impacts glioblastoma progression and survival, despite rare somatic mutations.

Purpose of the Study:

  • To provide a comprehensive review of the current literature on FGFRs in glioblastoma.
  • To summarize the biological functions of FGFRs in glioblastoma.
  • To discuss pharmacological approaches targeting FGFRs for glioblastoma treatment.

Main Methods:

  • Literature review of scientific articles on FGFRs and glioblastoma.
  • Analysis of studies detailing FGFR signaling pathways in brain tumors.
  • Examination of preclinical and clinical data on FGFR inhibitors.

Main Results:

  • FGFR signaling is implicated in glioblastoma pathogenesis and patient outcomes.
  • Small-molecule inhibitors targeting FGFR tyrosine kinases show therapeutic potential.
  • Targeting FGFRs represents a promising strategy for glioblastoma treatment.

Conclusions:

  • FGFRs are significant targets for glioblastoma therapy.
  • Further research into FGFR-targeted therapies is warranted.
  • Comprehensive understanding of FGFRs is crucial for advancing glioblastoma treatment.
Keywords:
FGFRastrocytomabrain cancerfibroblast growth factormalignant gliomareview

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