Related Experiment Video For MiR-296-5p
Updated: Jan 21, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression
Yanan Kong1, Lu Yang1, Weidong Wei1
1Department of Breast Oncology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Address: 651 East Dongfeng Road, Guangzhou, PR China.
Abstract:
Aim: To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. Materials & methods: We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments in vitro and in vivo were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and PLK1 in TNBC. Results & conclusion: CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion in vitro as well as tumor occurrence and metastasis in vivo. CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.
Related Concept Videos
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Facilitated Transport
Facilitated Transport
Social Facilitation
Facilitated Diffusion
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Scalar and Vector Triple Products
The scalar triple product is the dot product of a vector with the cross product of two vectors....

