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Updated: Jan 21, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Geriatric Physiology and the Frailty Syndrome
Kashif T Khan1, Kaveh Hemati2, Anne L Donovan3
1Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California, San Francisco, 505 Parnassus Avenue, Room M-917, San Francisco, CA 94143, USA.
Frailty syndrome, a measure of biologic age, predicts surgical outcomes better than chronologic age. Identifying and treating frailty in older patients improves perioperative care and outcomes.
Area of Science:
- Geriatric Medicine
- Surgical Patient Management
- Perioperative Care
Background:
- Geriatric physiology is essential for managing older surgical patients.
- Frailty syndrome captures biologic age and predicts adverse perioperative outcomes.
- Frailty is more predictive than chronologic age.
Purpose of the Study:
- To highlight the importance of frailty in perioperative risk stratification.
- To emphasize the role of frailty in decision-making for older surgical patients.
- To advocate for further research in frailty definition, screening, and treatment.
Main Methods:
- Review of current understanding of geriatric physiology and frailty.
- Analysis of frailty's predictive value in perioperative settings.
- Discussion of clinical applications in diagnosis, risk stratification, and treatment.
Main Results:
- Frailty syndrome is a key factor in assessing surgical risk in older adults.
- Frailty assessment offers a more accurate prediction of outcomes than chronological age.
- Utilizing frailty aids in effective patient management.
Conclusions:
- Frailty syndrome is a critical, modifiable factor in perioperative care for older adults.
- Further research is needed for a universal frailty definition and effective screening tools.
- Refining treatment programs for frail surgical patients is essential.
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