Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

229
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
229
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

191
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
191
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

234
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
234
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

199
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
199
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

243
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
243
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

230
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
230

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a core outcome set for clinical trials of extended reality for pain.

Pain reports·2026
Same author

Making the OR work: a socio-material study of ergonomics in the operating room.

The British journal of surgery·2026
Same author

Ammonia as a Hydrogen Carrier: Advances in Storage, Catalytic Decomposition, Kinetics, and Techno-Economic Analysis.

Chemical record (New York, N.Y.)·2026
Same author

Clinical Predictors of Antidepressant Effects of Ketamine and Esketamine in Treatment-Resistant Unipolar and Bipolar Depression: A Systematic Review.

CNS drugs·2026
Same author

Teaching ultrasound-guided regional anesthesia using remote immersive virtual reality: a randomized controlled trial.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same author

Mechanistic Insights Into Nickel-Based Catalysts for Ammonia Decomposition Toward Efficient Hydrogen Generation.

Chemical record (New York, N.Y.)·2026
Same journal

Outpatient Anesthesia in 2026: Scaling Care, Advancing Safety, Shaping the Future.

Anesthesiology clinics·2026
Same journal

Ambulatory Anesthesia: How Far Can We Go?

Anesthesiology clinics·2026
Same journal

Perioperative Management of Patients on Medication for Opioid Use Disorder Undergoing Ambulatory Surgery: Clinical Considerations for Anesthesiologists.

Anesthesiology clinics·2026
Same journal

Applying the 2024 American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines for Cardiac Evaluation and Managment of Patients Having Noncardiac Surgeries in an Ambulatory Setting.

Anesthesiology clinics·2026
Same journal

Comprehensive Review of Office-Based Anesthesia Safety 2026 for the Next Generation.

Anesthesiology clinics·2026
Same journal

A Contemporary Review on Health Care Disparities in Pediatric Ambulatory Anesthesia.

Anesthesiology clinics·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Using Generative Art to Convey Past and Future Climate Transitions
06:10

Using Generative Art to Convey Past and Future Climate Transitions

Published on: March 31, 2023

1.4K

Future Directions for Geriatric Anesthesiology.

Philippe Desmarais1, Nathan Herrmann2, Fahad Alam3

  • 1Cognitive & Movement Disorders Clinic, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A455, Toronto, Ontario M4N 3M5, Canada; L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

Anesthesiology Clinics
|July 25, 2019
PubMed
Summary
This summary is machine-generated.

Physicians must adapt care for the aging population, addressing unique needs in geriatric anesthesia and perioperative medicine. Future care models require system-level changes for older adults.

Keywords:
AnesthesiaEvidence-based medicineGeriatricsInnovationInterdisciplinary careMedical technologyPatient-centered outcomesPrecision medicine

More Related Videos

Kinematics and Ground Reaction Force Determination: A Demonstration Quantifying Locomotor Abilities of Young Adult, Middle-aged, and Geriatric Rats
10:28

Kinematics and Ground Reaction Force Determination: A Demonstration Quantifying Locomotor Abilities of Young Adult, Middle-aged, and Geriatric Rats

Published on: February 22, 2011

20.1K
An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research
06:16

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research

Published on: February 2, 2022

2.9K

Related Experiment Videos

Last Updated: Jan 21, 2026

Using Generative Art to Convey Past and Future Climate Transitions
06:10

Using Generative Art to Convey Past and Future Climate Transitions

Published on: March 31, 2023

1.4K
Kinematics and Ground Reaction Force Determination: A Demonstration Quantifying Locomotor Abilities of Young Adult, Middle-aged, and Geriatric Rats
10:28

Kinematics and Ground Reaction Force Determination: A Demonstration Quantifying Locomotor Abilities of Young Adult, Middle-aged, and Geriatric Rats

Published on: February 22, 2011

20.1K
An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research
06:16

An Experimental Approach to Investigating Effects of Artificial Light at Night on Free-Ranging Animals: Implementation, Results, and Directions for Future Research

Published on: February 2, 2022

2.9K

Area of Science:

  • Geriatric Medicine
  • Anesthesiology
  • Perioperative Care

Background:

  • The global population is aging rapidly, increasing the demand for specialized healthcare.
  • Older adults are major healthcare consumers with distinct medical and personal preferences.
  • Current geriatric anesthesia and perioperative care models have identified gaps.

Purpose of the Study:

  • To identify current deficiencies in geriatric anesthesia and perioperative care.
  • To project future advancements and necessary adaptations in healthcare for older patients.
  • To explore changes needed at patient, environmental, and specialty levels.

Main Methods:

  • Literature review of geriatric anesthesia and perioperative care.
  • Analysis of current healthcare system challenges for older adults.
  • Prospective outlook on future healthcare delivery for the aging population.

Main Results:

  • Significant gaps exist in current geriatric anesthesia and perioperative care.
  • The aging population requires tailored approaches considering their unique physiological and psychological profiles.
  • Healthcare systems need to evolve to meet the specific needs of older patients.

Conclusions:

  • Adaptation of medical and perioperative care is crucial for the aging demographic.
  • Future geriatric care necessitates a multi-faceted approach involving patients, environments, and the anesthesia specialty.
  • Proactive changes are essential to optimize healthcare outcomes for older adults.