Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecules and Compounds02:38

Molecules and Compounds

68.2K
Atoms and Molecules
68.2K
Types of Signaling Molecules01:32

Types of Signaling Molecules

12.8K
In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
12.8K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

31.2K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.2K
Positive Regulator Molecules01:45

Positive Regulator Molecules

134.6K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
134.6K
Positive Regulator Molecules02:39

Positive Regulator Molecules

6.6K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
6.6K
Negative Regulator Molecules01:23

Negative Regulator Molecules

38.3K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerating Proton Exchange in 1,8-Bis(dialkylamino)naphthalene Proton Sponges through Intramolecular Catalysis for CEST MRI.

Journal of the American Chemical Society·2026
Same author

CEST MRI Processing Pipeline in Pilot Study of Alzheimer's Disease Patients.

Magnetic resonance in medicine·2026
Same author

Evaluation of renal masses with CEST MRI: Protocol optimization and preliminary results.

Magnetic resonance in medicine·2025
Same author

Differentiation and characterization of healthy versus pathological tau using chemical exchange saturation transfer.

NMR in biomedicine·2024
Same author

CEST-MRI for body oncologic imaging: are we there yet?

NMR in biomedicine·2023
Same author

Inhomogeneous magnetization transfer imaging: Concepts and directions for further development.

NMR in biomedicine·2022

Related Experiment Video

Updated: Jan 21, 2026

Single-Molecule Imaging of Nuclear Transport
12:13

Single-Molecule Imaging of Nuclear Transport

Published on: June 9, 2010

13.8K

Imaging molecules.

Elena Vinogradov1

  • 1Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|July 25, 2019
PubMed
Summary
This summary is machine-generated.

Magnetic Resonance Imaging (MRI) offers high molecular specificity for visualizing endogenous molecules, despite lower sensitivity. This perspective explores methods like Spectroscopic Imaging (MRSI), Chemical Exchange Saturation Transfer (CEST), and Magnetization Transfer Contrast (MTC).

Keywords:
CESTMRIMRSIMTCMolecular imagingSpectroscopyihMTqMT

More Related Videos

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

18.7K
Transient Optical Clearing Using Absorbing Molecules for Ex Vivo and In Vivo Imaging
07:15

Transient Optical Clearing Using Absorbing Molecules for Ex Vivo and In Vivo Imaging

Published on: July 11, 2025

2.5K

Related Experiment Videos

Last Updated: Jan 21, 2026

Single-Molecule Imaging of Nuclear Transport
12:13

Single-Molecule Imaging of Nuclear Transport

Published on: June 9, 2010

13.8K
Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

18.7K
Transient Optical Clearing Using Absorbing Molecules for Ex Vivo and In Vivo Imaging
07:15

Transient Optical Clearing Using Absorbing Molecules for Ex Vivo and In Vivo Imaging

Published on: July 11, 2025

2.5K

Area of Science:

  • Biomedical Imaging
  • Molecular Biology
  • Medical Physics

Background:

  • Magnetic Resonance Imaging (MRI) is a powerful tool in molecular imaging, offering high molecular specificity.
  • While MRI's sensitivity is lower than some modalities, its ability to probe diverse biological processes is advantageous.
  • Living tissues present numerous molecular targets relevant to biology and medicine.

Purpose of the Study:

  • To provide a perspective on direct and indirect methods for visualizing endogenous molecules using MRI.
  • To briefly discuss key MRI techniques for molecular imaging, including MRSI, CEST, and MTC.
  • To contextualize molecular MRI within broader imaging and data integration trends.

Main Methods:

  • Focus on direct and indirect visualization of endogenous molecules via MRI.
  • Briefly discuss Spectroscopic Imaging (MRSI).
  • Briefly discuss Chemical Exchange Saturation Transfer (CEST) and Magnetization Transfer Contrast (MTC).

Main Results:

  • MRI provides high molecular specificity by leveraging various processes from intramolecular relaxation to water diffusion.
  • Techniques like MRSI, CEST, and MTC enable visualization of endogenous molecules.
  • Molecular MRI integrates with other imaging modalities and biological data.

Conclusions:

  • Molecular MRI is a rapidly advancing field with high specificity for endogenous molecules.
  • Various MRI techniques offer distinct advantages for molecular visualization.
  • The integration of molecular MRI data with other sources enhances biological and medical insights.