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Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
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Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

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Acute versus chronic myocardial injury and long-term outcomes

Erik Kadesjö1, Andreas Roos1, Anwar Siddiqui1

  • 1Functional Area of Emergency Medicine, Karolinska University Hospital, 14184, Stockholm.

Heart (British Cardiac Society)
|July 25, 2019
PubMed

Insights

Long-term prognosis for patients with acute myocardial injury and type 2 myocardial infarction is similar to chronic myocardial injury, with type 1 myocardial infarction showing the lowest mortality risk.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Biomarkers

Background:

  • Prognosis data for acute versus chronic myocardial injury is limited.
  • Understanding long-term outcomes is crucial for patient management.

Purpose of the Study:

  • To compare long-term prognosis in patients with acute myocardial injury, type 1 myocardial infarction (T1MI), type 2 myocardial infarction (T2MI), and chronic myocardial injury.
  • To investigate associations with all-cause mortality, myocardial infarction (MI), and heart failure.

Main Methods:

  • Observational cohort study of 3,853 patients with elevated high-sensitivity cardiac troponin T (hs-cTnT).
  • Patients categorized into acute myocardial injury, T1MI, T2MI, or chronic myocardial injury.
  • Adjusted hazard ratios (HRs) calculated for mortality and adverse events.

Main Results:

  • Patients with acute myocardial injury had higher adjusted risks of death (HR 1.21) and heart failure (HR 1.24) compared to chronic myocardial injury.
  • Type 1 myocardial infarction (T1MI) showed a lower adjusted risk of death (HR 0.86) but a higher risk of MI (HR 2.09).
  • Type 2 myocardial infarction (T2MI) demonstrated higher adjusted risks of death (HR 1.46) and heart failure (HR 1.30).

Conclusions:

  • Long-term mortality risks are similar between acute myocardial injury and chronic myocardial injury, with T2MI showing higher risks.
  • Type 1 myocardial infarction (T1MI) is associated with the lowest long-term mortality.
  • Both acute and chronic myocardial injury represent significant risks for adverse outcomes.
Abstract

Keywords:
cardiac risk factors and preventioncoronary artery diseaseepidemiology

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