Modelling approaches for studying the microbiome

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Manish Kumar1,2, Boyang Ji1, Karsten Zengler2,3,4

  • 1Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.

Nature Microbiology
|July 25, 2019
PubMed

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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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