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Infection phase is a predictor of pruritus in patients with hepatitis B virus infection

Satoshi Oeda1, Hirokazu Takahashi2, Hiroshi Isoda2

  • 1Liver Center, Saga University, Saga-Shi, Saga 849-8501, Japan.

Biomedical Reports
|July 25, 2019
PubMed

Insights

Pruritus is less common in the inactive phase of chronic hepatitis B (CHB) compared to the immune-active phase. Inactive CHB is an independent protective factor against pruritus in hepatitis B virus patients.

Area of Science:

  • Hepatology
  • Viral Hepatitis
  • Dermatology

Background:

  • Pruritus is a frequent symptom in liver diseases, including chronic hepatitis B (CHB).
  • Hepatitis B virus (HBV) infection has distinct phases, but their independent effect on pruritus is not well-defined.

Purpose of the Study:

  • To investigate the association between HBV infection phase and pruritus in patients with CHB.
  • To determine if the inactive CHB phase independently influences pruritus prevalence.

Main Methods:

  • Retrospective analysis of 196 CHB patients from a cohort of 1,631.
  • One-to-one propensity score matching (13 variables) comparing immune-active and inactive CHB phases.
  • Pruritus prevalence assessed via patient interviews.

Main Results:

  • Pruritus prevalence was significantly lower in the inactive CHB phase (23%) versus the immune-active phase (47%; P=0.031).
  • Inactive CHB phase was identified as an independent protective factor against pruritus (OR, 0.35; 95% CI, 0.143-0.842; P=0.019).

Conclusions:

  • The inactive phase of CHB is associated with a reduced risk of pruritus.
  • Progression to the inactive CHB phase may alleviate pruritus in patients with HBV infection.

Keywords:
dermatologyhepatitis Bitchingpropensity scorepruritus

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