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Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice
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Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice

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Microglial activation after ischaemic stroke

Shengxiang Zhang1

  • 1Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, China.

Stroke and Vascular Neurology
|July 25, 2019
PubMed

Insights

Microglia, the brain's immune cells, rapidly activate after ischemic stroke. Their role in neuroinflammation and recovery remains unclear, but imaging shows activation correlates with stroke severity.

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Ischemic stroke triggers rapid microglial activation in the central nervous system.
  • Microglial activation is implicated in neuroinflammation and the progression of ischemic tissue damage.
  • Key events include microglial morphological changes, proliferation, and polarization.

Purpose of the Study:

  • To review the morphological and functional aspects of microglial activation post-ischemic stroke.
  • To highlight advancements in two-photon imaging for studying microglial responses.
  • To discuss the unclear role of activated microglia in post-stroke recovery.

Main Methods:

  • Review of existing literature on microglial activation after ischemic stroke.
  • Focus on studies utilizing confocal and two-photon imaging techniques.
  • Analysis of morphological and functional characteristics of activated microglia.

Main Results:

  • Microglial activation is a rapid and stereotypical response to ischemic stroke.
  • The degree of microglial activation correlates with the severity of ischemia.
  • Activated microglia exhibit diverse polarization phenotypes.

Conclusions:

  • The precise role of activated microglia (beneficial or detrimental) in post-stroke recovery requires further investigation.
  • Two-photon imaging provides valuable insights into microglial dynamics during ischemic events.
  • Understanding microglial activation is crucial for developing therapeutic strategies for ischemic stroke.
Keywords:
activationischaemic strokemicrogliatwo-photon imaging

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