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Updated: Jan 21, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
An Improved Full Convolutional Network Combined with Conditional Random Fields for Brain MR Image Segmentation
1Department of Neurology, Xi'an XD Group Hospital, Xi'an, 710077, Shaanxi, China. Zhaijiemin88@163.com.
Abstract:
Existing brain region segmentation algorithms based on deep convolutional neural networks (CNN) are inefficient for object boundary segmentation. In order to enhance the segmentation accuracy of brain tissue, this paper proposed an object region segmentation algorithm that combines pixel-level information and semantic information. Firstly, we extract semantic information by CNN with the attention module and get the coarse segmentation results through a specific pixel-level classifier. Then, we exploit conditional random fields to model the relationship between the underlying pixels so as to get local features. Finally, the semantic information and the local pixel-level information are respectively used as the unary potential and the binary potential of the Gibbs distribution, and the combination of both can obtain the fine region segmentation algorithm based on the fusion of pixel-level information and the semantic information. A large number of qualitative and quantitative test results show that our proposed algorithm has higher precision than the existing state-of-the-art deep feature models, which can better solve the problem of rough edge segmentation and produce good 3D visualization effect.
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