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LIN28A gene polymorphisms confer Wilms tumour susceptibility: A four-centre case-control study.

Zhenjian Zhuo1,2, Wen Fu1, Jiabin Liu1

  • 1Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Journal of Cellular and Molecular Medicine
|July 25, 2019
PubMed
Summary

Genetic variations in the LIN28A gene, specifically polymorphisms rs3811463 and rs34787247, are linked to a higher risk of developing Wilms tumour in children. These findings suggest a potential genetic predisposition to this childhood kidney cancer.

Keywords:
LIN28AWilms tumourcase-control studypolymorphismsusceptibility

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Area of Science:

  • Genetics
  • Pediatric Oncology
  • Molecular Biology

Background:

  • Wilms tumour is a common childhood kidney cancer.
  • LIN28A gene overexpression is implicated in various cancers.
  • The role of LIN28A in Wilms tumour development requires further investigation.

Purpose of the Study:

  • To investigate the association between LIN28A gene polymorphisms and Wilms tumour risk.
  • To identify specific single nucleotide polymorphisms (SNPs) associated with increased Wilms tumour susceptibility.

Main Methods:

  • Genotyping of four LIN28A polymorphisms (rs3811464, rs3811463, rs34787247, rs11247957) in 355 Wilms tumour patients and 1070 healthy controls.
  • Statistical analysis including overall, combination, and stratified analyses.
  • Expression quantitative trait locus (eQTL) analysis to assess allele-specific gene expression.

Main Results:

  • SNPs rs3811463 T>C and rs34787247 G>A were significantly associated with increased Wilms tumour risk.
  • Carrying one or multiple risk genotypes correlated with a higher likelihood of developing Wilms tumour (ORs 1.58 and 1.56).
  • The rs3811463 C allele was linked to increased LIN28A gene transcripts, suggesting a functional impact.

Conclusions:

  • LIN28A gene polymorphisms, particularly rs3811463 and rs34787247, may contribute to an increased predisposition to Wilms tumour.
  • These genetic variations could serve as potential biomarkers for Wilms tumour risk assessment.
  • Further research is warranted to elucidate the precise mechanisms underlying LIN28A's role in Wilms tumour pathogenesis.