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Can Nesfatin-1 Predict Hypertension in Obese Children?
Hatice Güneş1, Filiz Alkan Baylan2, Hakan Güneş3
1Sütçü İmam University Faculty of Medicine, Department of Pediatrics, Kahramanmaraş, Turkey
Journal of Clinical Research in Pediatric Endocrinology
|July 25, 2019
Summary
Higher Nesfatin-1 levels are linked to hypertension in obese children. This peptide, along with copper levels and BMI, independently predicts high blood pressure in this population.
Area of Science:
- Pediatrics
- Endocrinology
- Cardiology
Background:
- Childhood obesity is a growing concern, often leading to hypertension.
- The specific mechanisms linking obesity to hypertension are not fully understood.
- Nesfatin-1, a peptide influencing appetite, also affects blood pressure.
Purpose of the Study:
- To investigate the relationship between Nesfatin-1 levels and hypertension in obese children.
- To identify predictors of obesity-related hypertension.
Main Methods:
- A cross-sectional study involving 87 obese children, divided into hypertensive and normotensive groups.
- Measurement of serum Nesfatin-1 concentrations and trace elements (Zinc, Copper).
- Analysis of Body Mass Index (BMI) and weight Z-scores.
Main Results:
- Hypertensive obese children had higher BMI, weight, and Nesfatin-1 levels.
- Lower serum Copper levels were observed in the hypertensive group.
- Nesfatin-1, Copper, and BMI for age Z-score were significant independent predictors of hypertension.
Conclusions:
- Elevated Nesfatin-1 levels are associated with hypertension in obese children.
- Nesfatin-1 is an independent predictor of hypertension in this cohort.
- Serum Copper levels and BMI are also crucial factors in obesity-related hypertension.
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