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Minor variant of AHSG gene 767C>G polymorphism may decrease the risk of gestational diabetes mellitus.

Halit Akbas1, Suna Kahraman1, Sibel Sak2

  • 1Department of Medical Biology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|July 25, 2019
PubMed
Summary

The homozygous GG genotype of the alpha-2-Heremans Schmid glycoprotein (AHSG) gene 767C>G polymorphism may offer protection against gestational diabetes mellitus (GDM). This finding suggests a potential biomarker for predicting GDM development.

Keywords:
AHSG geneFetuin Agestational diabetes mellituspolymorphismsreal-time PCR

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Area of Science:

  • Genetics
  • Endocrinology
  • Obstetrics

Background:

  • Insulin resistance is a key factor in gestational diabetes mellitus (GDM) development.
  • Fetuin A, a serum protein that increases during pregnancy, inhibits insulin receptor tyrosine kinase and is linked to insulin resistance.
  • The alpha-2-Heremans Schmid glycoprotein (AHSG) gene encodes fetuin A, and its polymorphisms may influence GDM risk.

Purpose of the Study:

  • To investigate the association between AHSG gene polymorphisms (-843A>T and 767C>G) and GDM.
  • To determine if specific AHSG genotypes correlate with an increased or decreased risk of developing GDM.

Main Methods:

  • Case-control study involving 83 pregnant women with GDM and 100 healthy pregnant women.
  • Genotyping of AHSG gene polymorphisms using TaqMan allelic discrimination assay with real-time PCR.
  • Statistical analysis to compare genotype distributions between GDM and control groups.

Main Results:

  • The homozygous GG genotype of the AHSG gene 767C>G polymorphism was significantly less frequent in the GDM patient group (p < 0.05).
  • No statistically significant difference in genotype distribution was observed for the AHSG gene -843A>T polymorphism between groups (p > 0.05).

Conclusions:

  • The homozygous GG variant of the AHSG gene 767C>G polymorphism may confer a protective effect against GDM development.
  • This specific AHSG genotype could potentially serve as a molecular biomarker for predicting GDM risk.
  • Further research with larger sample sizes is recommended to validate these findings.