Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Histology01:27

Liver Histology

4.1K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.1K
Liver Physiology01:30

Liver Physiology

3.5K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.5K
Liver Regeneration01:24

Liver Regeneration

4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

2.0K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.0K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.9K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.9K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

186
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
186

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative biliary drainage in perihilar cholangiocarcinoma: retrospective multicentre analysis.

BJS open·2026
Same author

Thyroid dose guidance in elective supraclavicular breast radiotherapy: a national survey of practice patterns in Switzerland.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2026
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026

Related Experiment Video

Updated: Jan 21, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

17.4K

Mortality after liver surgery in Germany.

N Filmann1, D Walter2, E Schadde3,4,5

  • 1Institute of Biostatistics and Mathematical Modelling, Frankfurt University Hospital, Goethe-University Frankfurt/Main, Frankfurt/Main, Germany.

The British Journal of Surgery
|July 25, 2019
PubMed
Summary
This summary is machine-generated.

Hospital mortality after liver resection in Germany remains high, particularly for complex procedures. Centralizing liver surgery and further research are recommended to improve patient outcomes.

More Related Videos

Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

12.2K
Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation
05:25

Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation

Published on: June 14, 2024

984

Related Experiment Videos

Last Updated: Jan 21, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

17.4K
Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

12.2K
Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation
05:25

Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation

Published on: June 14, 2024

984

Area of Science:

  • Hepatobiliary surgery
  • Surgical outcomes research
  • Health services research

Background:

  • Liver resection is performed in over 1000 German hospitals without central regulation of infrastructure or quality.
  • Mortality rates following liver surgery in Germany are not well-documented.

Purpose of the Study:

  • To analyze hospital mortality rates after liver resection in Germany.
  • To identify factors influencing outcomes and explore potential improvements in care delivery.

Main Methods:

  • Analysis of standardized hospital discharge data (Diagnosis-Related Groups, ICD-10, German operations and procedure key codes) from 2010-2015.
  • Inclusion of 110,332 liver procedures, with specific focus on major hepatic procedures and colorectal liver metastases (CRLM) surgery.

Main Results:

  • Overall hospital mortality was 5.8%, with major hepatic procedures at 10.4%.
  • Mortality varied by cancer type, highest in extrahepatic cholangiocarcinoma (14.6%) and extended hepatectomy (16.2%).
  • A significant volume-outcome relationship was observed, with very high-volume centers showing lower mortality (4.6%) compared to low-volume hospitals (7.5%) for CRLM surgery.

Conclusions:

  • Hospital mortality after liver resection in Germany is high and requires focused research.
  • Consideration of centralizing liver surgery may improve outcomes.
  • Failure to rescue after complications significantly increases mortality.