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Multicenter performance evaluation of the Abbott Alinity hq hematology analyzer
Christiaan L Slim1, Brigitte A Wevers2, Martijn W H J Demmers3
1Department of Clinical Chemistry, Location Medical Center Leeuwarden, Certe Medical Diagnostics & Advice, Leeuwarden, The Netherlands.
Clinical Chemistry and Laboratory Medicine
|July 25, 2019
Summary
The Alinity hq hematology analyzer shows strong agreement for complete blood count parameters and white blood cell differentials, making it suitable for clinical labs. It offers reliable performance comparable to existing systems.
Area of Science:
- Hematology
- Clinical Laboratory Science
- Medical Diagnostics
Background:
- Introduction of the Alinity hq, a novel high-throughput hematology analyzer utilizing optical principles.
- The analyzer reports 29 parameters, including a six-part white blood cell differential.
- Need for comprehensive evaluation of its analytical and clinical performance.
Purpose of the Study:
- To evaluate the analytical and clinical performance of the Alinity hq hematology analyzer.
- Comparison with established systems like CELL-DYN Sapphire and manual differentials.
Main Methods:
- Multicenter study involving 1473 whole-blood samples across three clinical laboratories in the Netherlands.
- Comparison of complete blood count (CBC) results and morphological flagging against CELL-DYN Sapphire and manual differentials.
- Assessment of analytical performance metrics: precision, linearity, limit of quantitation, carryover, and sample stability.
Main Results:
- Strong concordance observed between Alinity hq and CELL-DYN Sapphire for most CBC parameters, with notable exception of basophil granulocytes.
- Alinity hq demonstrated high agreement with manual white blood cell differentials, outperforming CELL-DYN Sapphire in basophil agreement.
- Sensitivity for Blast flag detection was 57.6%, increasing to 70.0% for samples with ≥5% blasts. Analytical performance met state-of-the-art standards.
Conclusions:
- Alinity hq CBC measurands show good overall agreement with CELL-DYN Sapphire and manual white blood cell differentials.
- The analyzer's analytical and clinical performance characteristics are suitable for routine use in clinical laboratories.
- Alinity hq presents a viable option for high-throughput hematology analysis.
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