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Sodium cromoglycate in asthma: correlation between response and serum concentrations
Y Yahav1, S Dany, D Katznelson
1Harry Shwachman Clinic, Department of Pediatrics A, Tel-Hashomer, Israel.
Archives of Disease in Childhood
|June 1, 1988
Summary
This study found that children with asthma who inhaled sodium cromoglycate showed a clinical response that correlated with serum concentrations of the medication. Better inhalation technique also led to higher serum levels and improved asthma control.
Area of Science:
- Pediatric Pulmonology
- Clinical Pharmacology
- Respiratory Medicine
Background:
- Sodium cromoglycate is an inhaled medication used for asthma management.
- Understanding the relationship between drug concentration and clinical effect is crucial for optimizing treatment.
- Previous studies have explored sodium cromoglycate efficacy, but direct correlation with serum levels requires further investigation.
Purpose of the Study:
- To investigate the correlation between serum concentrations of sodium cromoglycate and clinical response in children with asthma.
- To assess the impact of inhalation technique on serum drug levels and treatment outcomes.
Main Methods:
- A 10-week trial involving 25 children with asthma, including a 2-week baseline and 8-week treatment period.
- Inhalation of 20 mg sodium cromoglycate four times daily.
- Clinical response measured by symptomless days, daily symptom scores, and peak expiratory flow rate.
- Serum sodium cromoglycate concentrations measured by radioimmunoassay post-inhalation.
- Inhalation technique graded at the end of the treatment period.
Main Results:
- Significant correlation found between clinical response parameters (symptomless days, daily symptom score, peak expiratory flow rate) and the area under the serum concentration-time curve.
- Both the area under the sodium cromoglycate concentration-time curve and clinical response significantly correlated with the inhalation technique score.
- Higher serum concentrations were associated with better clinical outcomes.
Conclusions:
- Serum concentrations of sodium cromoglycate achieved through inhalation correlate significantly with clinical response in pediatric asthma.
- Effective inhalation technique is a key factor in achieving therapeutic serum levels and improving treatment outcomes.
- These findings suggest that monitoring or optimizing inhalation technique may enhance the effectiveness of sodium cromoglycate therapy in children.