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High Level of Lipoprotein(a) as Predictor for Recurrent Heart Failure in Patients with Chronic Heart Failure: a

Jianlong Yan1, Yanbin Pan2, Junhui Xiao1

  • 1Huadu District People's Hospital, Southern Medical University - Cardiology, Guangzhou - China.

Arquivos Brasileiros De Cardiologia
|July 25, 2019
PubMed

Insights

Elevated Lipoprotein(a) [Lp(a)] levels are linked to recurrent heart failure (HF) in patients with coronary heart disease (CHD). This study found Lp(a) is an independent predictor of recurrent HF in this population.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Biomarkers

Background:

  • Elevated Lipoprotein(a) [Lp(a)] is a known risk factor for atherosclerotic vascular disease.
  • Limited data exist on the association between Lp(a) and recurrent heart failure (HF) in patients with chronic HF due to coronary heart disease (CHD).

Purpose of the Study:

  • To investigate the prognostic impact of elevated Lp(a) levels on recurrent HF in patients with chronic HF caused by CHD.

Main Methods:

  • A cohort of 309 patients with chronic HF and CHD was divided into high and low Lp(a) groups based on the median level (20.6 mg/dL).
  • Kaplan-Meier analysis and multivariate Cox regression were used to assess the association between Lp(a) levels and recurrent HF incidence over a median follow-up of 186 days.

Main Results:

  • Patients with higher Lp(a) levels exhibited a significantly higher incidence of recurrent HF (log-rank < 0.0001).
  • Multivariate analysis confirmed that Lp(a) levels were independently correlated with recurrent HF incidence (HR: 2.720, p < 0.0001).

Conclusions:

  • In Chinese patients with chronic HF caused by CHD, elevated Lp(a) levels are independently associated with an increased risk of recurrent HF.
  • Lp(a) may serve as a valuable prognostic biomarker for recurrent HF in this patient group.
Abstract

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