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[Blood platelets and asthma caused by aspirin]
Allergie Et Immunologie
|October 1, 1987
Summary
Platelets from aspirin-induced asthma (ASA) patients exhibit abnormal responses to NSAID and aspirin, producing cytocidal molecules. Sodium salicylate may offer a new therapeutic approach for aspirin-sensitive intolerance.
Area of Science:
- Biochemistry
- Immunology
- Pharmacology
Context:
- Platelets from aspirin-induced asthma (ASA) patients show unique in vitro reactions to aspirin and NSAID.
- These reactions involve the generation of cytocidal molecules and oxygen-dependent free radicals.
Purpose:
- To investigate the abnormal platelet response in ASA patients to NSAID and aspirin.
- To elucidate the underlying biochemical pathways and potential therapeutic interventions.
Summary:
- ASA patient platelets, unlike those from normal donors or allergic asthmatics, generate cytocidal molecules and free radicals upon exposure to aspirin/NSAID.
- This abnormality is linked to NSAID/aspirin inhibition of the cyclo-oxygenase pathway, affecting prostaglandin PGH2 binding.
- A poorly defined lipoxygenase metabolite also appears to contribute to the anomaly.
Impact:
- Sodium salicylate, a well-tolerated aspirin metabolite, inhibits these abnormal platelet responses.
- This finding suggests novel therapeutic strategies for managing aspirin-sensitive intolerance.