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Quorum Sensing Inhibition by Marine Bacteria
Anabela Borges1, Manuel Simões2
1LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal. apborges@fe.up.pt.
Marine Drugs
|July 26, 2019
Summary
Antibiotic resistance is a major global challenge. This review explores novel antivirulence strategies, focusing on quorum sensing inhibitors derived from marine bacteria to combat pathogenic bacteria.
Area of Science:
- Microbiology
- Pharmacology
- Marine Biotechnology
Background:
- Rising antibiotic resistance poses a significant threat to public health.
- Traditional antibiotics face challenges due to increasing bacterial resistance.
- Novel strategies are needed to control clinically significant pathogenic bacteria.
Purpose of the Study:
- To review bacterial intercellular communication mechanisms, particularly in biofilm formation.
- To explore the potential of marine bacteria and their compounds as quorum sensing inhibitors.
- To highlight antivirulence therapies as an alternative to traditional antibiotics.
Main Methods:
- Literature review of bacterial quorum sensing (QS) mechanisms.
- Analysis of QS pathways involved in biofilm formation.
- Overview of marine bacteria and their bioactive components with QS inhibitory potential.
Main Results:
- Bacterial communication is crucial for pathogenesis and biofilm development.
- Quorum sensing (QS) pathways regulate key virulence factors.
- Marine bacteria represent a promising source of novel QS inhibitors.
Conclusions:
- Antipathogenic and antivirulence therapies targeting QS offer a promising strategy.
- Disarming pathogens rather than eradicating them may mitigate resistance development.
- Marine bioactive compounds show potential for developing new anti-infective agents.
Keywords:
antimicrobial resistanceantipathogenic and antivirulencemarine bacteriaquorum quenchingquorum sensingselective pressureMore Related Videos
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