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The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
Magdalena Rudzińska1, Alessandro Parodi1, Surinder M Soond1
1Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Abstract:
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
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