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Wheat Allergy in Children: A Comprehensive Update.

Giampaolo Ricci1, Laura Andreozzi2, Francesca Cipriani2

  • 1Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, 40139 Bologna, Italy. giampaolo.ricci@unibo.it.

Medicina (Kaunas, Lithuania)
|July 26, 2019
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Summary
This summary is machine-generated.

Wheat allergy, an IgE-mediated disorder, affects children, often resolving by school age. Early anaphylaxis or high IgE levels may indicate persistent wheat allergy, managed by diet or emerging oral immunotherapy.

Keywords:
Triticum aestivumanaphylaxisasthmafood allergyrecombinant allergenwheat

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Area of Science:

  • Pediatric Allergy and Immunology
  • Gastroenterology
  • Immunology

Background:

  • Gluten-related disorders are common in children.
  • Wheat allergy, an IgE-mediated condition, affects less than 1% in Europe and presents diverse clinical manifestations.
  • Risk factors for wheat allergy are still under investigation.

Purpose of the Study:

  • To review the current understanding of wheat allergy in pediatric patients.
  • To discuss diagnostic criteria, clinical presentations, and prognosis.
  • To explore current and emerging management strategies for wheat allergy.

Main Methods:

  • Literature review of studies on pediatric wheat allergy.
  • Analysis of epidemiological data and risk factors.
  • Evaluation of clinical manifestations and diagnostic approaches.

Main Results:

  • The prognosis for IgE-mediated wheat allergy in children is generally favorable, with most outgrowing it.
  • Factors like early anaphylaxis and high wheat-specific IgE increase the risk of persistent allergy.
  • Dietary avoidance is the primary management, with oral immunotherapy showing promise.

Conclusions:

  • Wheat allergy in children typically has a good prognosis, but persistent cases require careful monitoring.
  • Oral immunotherapy presents a potential future treatment for promoting tolerance in wheat-allergic children.
  • Further research is needed to optimize oral immunotherapy protocols for pediatric wheat allergy.