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Related Experiment Video

Updated: Jan 21, 2026

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses
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Plants and Phytocompounds Active Against Bothrops Venoms.

Roberta Jeane Bezerra Jorge1, René Duarte Martins2, Renata Mendonça Araújo3

  • 1Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Brazil.

Current Topics in Medicinal Chemistry
|July 26, 2019
PubMed
Summary
This summary is machine-generated.

Snakebite envenomation by Bothrops species causes severe tissue damage. This review explores promising plant-derived compounds as complementary treatments to antivenom for improving snakebite therapy.

Keywords:
Anti-bothropic serumBothropsMedicinal plantsNatural inhibitorsSecondary metabolitesSnakebite envenomation.

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Area of Science:

  • Toxicology
  • Pharmacognosy
  • Tropical Medicine

Background:

  • Snakebite envenomation, particularly by Bothrops species in Latin America, presents a significant health burden with severe local tissue damage.
  • Current antivenom therapy effectively neutralizes systemic effects but struggles to mitigate local damage like swelling, hemorrhaging, and myonecrosis.
  • Developing improved treatments is crucial to address the limitations of existing antivenom and reduce the impact on victims.

Purpose of the Study:

  • To review promising plants and phytocompounds with activity against Bothrops venoms.
  • To identify potential natural compounds that can complement antivenom therapy by targeting local tissue damage.
  • To explore ethnopharmacological knowledge for novel snakebite treatment strategies.

Main Methods:

  • Literature review of scientific articles and ethnopharmacological data.
  • Identification and analysis of plant-derived compounds reported to have activity against snake venom components.
  • Focus on compounds targeting toxins responsible for local tissue damage.

Main Results:

  • Several plant species and their isolated compounds show potential in neutralizing Bothrops venom-induced local effects.
  • Phytocompounds offer a promising avenue for developing adjunct therapies to conventional antivenom.
  • Traditional medicinal uses of plants against snakebites are being validated by scientific research.

Conclusions:

  • Natural compounds from plants represent a valuable resource for developing novel snakebite treatments.
  • Further research into these phytocompounds could lead to more effective therapies for Bothrops envenomation.
  • Integrating phytotherapy with antivenom may offer a more comprehensive approach to managing snakebite injuries.