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The association between high-sensitivity C-reactive protein and blood pressure in Yi people
Li Pan1, Guoju Li2, Shaoping Wan3
1Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Insights
High-sensitivity C-reactive protein (hs-CRP) is common in Yi adults. This study found no link between hs-CRP levels and the risk of prehypertension or hypertension in this population.
Area of Science:
- Cardiovascular Health
- Biomarkers
- Population Health
Background:
- High-sensitivity C-reactive protein (hs-CRP) is a recognized cardiovascular disease risk factor.
- The association between hs-CRP and blood pressure in Yi adults remains unstudied.
- This research addresses the knowledge gap regarding hs-CRP and hypertension in the Yi population.
Purpose of the Study:
- To investigate the relationship between hs-CRP levels and blood pressure.
- To determine if hs-CRP is a risk factor for prehypertension or hypertension in Yi adults.
Main Methods:
- A cross-sectional study involving 2916 Yi adults (migrants and farmers) aged 20-80 years.
- Stratified cluster sampling used for participant recruitment in Sichuan Province.
- Directed acyclic graphs and multiple regression analyses employed to assess hs-CRP's effect on blood pressure and hypertension prevalence.
Main Results:
- The prevalence of high hs-CRP (>3 mg/L) was 23.25% among Yi adults.
- A significant association was observed between hs-CRP >3 mg/L and lower pulse pressure (PP).
- No significant association was found between hs-CRP levels and the prevalence of prehypertension or hypertension.
Conclusions:
- High hs-CRP is prevalent within the Yi population.
- This study does not support hs-CRP as a risk factor for prehypertension or hypertension in Yi adults.
- Further research may explore other factors influencing cardiovascular health in this demographic.
Background:
High-sensitivity C-reactive protein (hs-CRP) is a common risk factor for developing cardiovascular disease. However, there has been no study reporting the relationship between hs-CRP and blood pressure in Yi adults. The aim of this study is to investigate the association between hs-CRP and blood pressure in Yi adults.
Methods:
In this cross-sectional study, included subjects were 2916 Yi migrants or farmers aged 20-80 years, recruited by using a stratified cluster sampling method from Liangshan Yi Autonomous Prefecture of Sichuan Province in 2014. The directed acyclic graphs(DAG) was used to select a minimal sufficient adjustment sets of variables which would identification the unconfounded effect of hs-CRP and hypertension. Multiple linear and multinomial logit analysis were used to estimate the effect of hs-CRP on SBP/DBP/MAP/PP and the prevalence of prehypertension/hypertension after adjustment for the relevant confounders.
Results:
The median level of hs-CRP was 1.20 (0.50-3.06)mg/L in Yi migrants, and 0.84(0.36-2.52) mg/L in Yi farmers, and the prevalence of high hs-CRP was 23.25%. For hs-CRP > 3 mg/L group, the adjusted PP tended to have lower values (β = - 1.49, 95%CI: - 2.49--0.49, P = 0.0034) compared with < 1 mg/L group. After adjusting for confounders, there were no significant association between hs-CRP and prehypertension/hypertension (P > 0.05).
Conclusions:
Our results suggest that high hs-CRP is prevalent in Yi people, and this study does not support hs-CRP as a risk factor of prehypertension or hypertension.
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