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A regioselectivity switch in Pd-catalyzed hydroallylation of alkynes
Ding-Wei Ji1,2, Yan-Cheng Hu1, Hao Zheng1,2
1Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian 116023 , P. R. China .
Abstract:
By exploiting the reactivity of a vinyl-Pd species, we control the regioselectivity in hydroallylation of alkynes under Pd-hydride catalysis. A monophosphine ligand and carboxylic acid combination promotes 1,5-dienes through a pathway involving isomerization of alkynes to allenes. In contrast, a bisphosphine ligand and copper cocatalyst favor 1,4-dienes via a mechanism that involves transmetalation. Our study highlights how to access different isomers by diverting a common organometallic intermediate.
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