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Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology
Published on: July 12, 2022
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Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study
Pragya Kosta1, David J Warren2, Gianluca Lazzi3,4
1Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA.
Healthcare Technology Letters
|July 26, 2019
Summary
Magnetic neural stimulation using an array of coils offers precise control for selective nerve activation. This method shows promise for targeted neurostimulation applications, outperforming traditional electrical methods.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Computational Modeling
Background:
- Electrical stimulation is a common method for neural activation but often lacks selectivity.
- Achieving precise control over neural activation is crucial for therapeutic applications.
Purpose of the Study:
- To computationally investigate magnetic neural stimulation (MNS) as a selective alternative to electrical stimulation.
- To assess the efficacy of a multi-coil array for targeted rat sciatic nerve stimulation.
Main Methods:
- Development of a 3D heterogeneous multi-resolution model of the rat sciatic nerve.
- Utilizing the impedance method to compute magnetic and electric fields.
- Defining and applying a 'selectivity index' to quantify activation precision.
Main Results:
- An array of four mm-sized coils demonstrated effective selective stimulation of targeted nerve fascicles.
- Predicted selectivity index values of 0.75 or better for targeted regions.
- The coil array provided superior spatial control over induced electric fields compared to single coils.
Conclusions:
- Magnetic neural stimulation with a coil array offers enhanced spatial control for selective neurostimulation.
- This approach presents a viable alternative to electrical stimulation for applications requiring precise neural targeting.
Keywords:
array configurationbioelectric phenomenabioelectric potentialsbiological tissuesbiomagnetismbiomedical electrodeselectric fieldselectrical stimulationmagnetic fieldsmagnetic neural stimulationmm-size magnetic coilsmuscleneuromuscular stimulationneurophysiologynontargeted regionsperformance metricphysiological modelsrat sciatic nerveselective activationselective neural stimulationselective neurostimulationselective stimulationselectivity indexsingle coiltargeted regionthree-dimensional heterogeneous multiresolution nerve modeltraditional extraneural electrode arrays
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