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Related Experiment Videos

Possible virulence marker for Streptococcus agalactiae (Lancefield Group B).

G Orefici1, S Recchia, L Galante

  • 1Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanità, Rome, Italy.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|April 1, 1988
PubMed
Summary

Increased virulence in Streptococcus agalactiae (Strep B) strains after mouse passage correlated with higher sialic acid and a common antigen. This antigen was found in clinical isolates from infections but not carriers.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Bacterial Pathogenesis

Background:

  • Streptococcus agalactiae (Group B Strep) is a significant human pathogen.
  • Understanding virulence factors is crucial for combating Strep B infections.

Purpose of the Study:

  • To investigate changes in Streptococcus agalactiae virulence following mouse passage.
  • To identify potential virulence-associated markers in Strep B.

Main Methods:

  • Serial mouse passage of Streptococcus agalactiae strains from various serotypes.
  • Quantification of sialic acid content.
  • Detection of common antigens using immunological methods.
  • Comparison of antigen presence in clinical isolates from infected individuals versus carriers.

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Main Results:

  • Mouse passage led to increased virulence in all tested Streptococcus agalactiae serotypes.
  • Increased virulence was associated with elevated sialic acid levels.
  • A common antigen appeared in passaged strains.
  • This antigen was present in most clinical isolates from infected babies and diabetic adults, but absent in isolates from carriers.

Conclusions:

  • Serial mouse passage enhances Streptococcus agalactiae virulence.
  • Sialic acid content and a common antigen are associated with increased virulence.
  • The common antigen may serve as a marker distinguishing invasive strains from carrier strains.