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How I approach hereditary cancer predisposition in a child with cancer
Michaela Kuhlen1, Dagmar Wieczorek2, Reiner Siebert3
1University Children's Hospital Augsburg, Swabian Children's Cancer Center, Augsburg, Germany.
Abstract:
Approximately 10% of all children with cancer are affected by a monogenic cancer predisposition syndrome. This has important implications for both the child and her/his family. The assessment of hereditary cancer predisposition is a challenging task for clinicians and genetic counselors in daily routine. It includes consideration of tumor genetics, specific features of the patient, and the medical/family history. To keep up with the pace of this rapidly evolving and increasingly complex field of genetic susceptibility, we suggest a systematic approach for the evaluation of the child with cancer and her/his family by an interdisciplinary team specialized in hereditary cancer predisposition.
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