Related Experiment Video
Updated: Jan 21, 2026
08:11
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
Published on: November 14, 2016
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Changes in temporal features of speech in secondary progressive multiple sclerosis (SPMS) - case studies
Veronika Svindt1, Judit Bóna2, Ildikó Hoffmann1,3
1Department of Psycholinguistics, Neurolinguistics and Sociolinguistics, Research Institute for Linguistics of the Hungarian Academy of Sciences, Budapest, Hungary.
Clinical Linguistics & Phonetics
|July 26, 2019
Summary
Multiple sclerosis (MS) significantly impacts speech production, causing slower speech, articulation, and increased pauses. Cognitive load exacerbates these speech difficulties in MS patients compared to healthy individuals.
Area of Science:
- Neurology
- Speech-Language Pathology
Background:
- Multiple sclerosis (MS) is a chronic inflammatory disease affecting neurological functions, including motor and cognitive abilities.
- Speech and language disorders are common in MS, impacting patient quality of life, yet are understudied.
- This research investigates speech production and temporal suprasegmental characteristics in progressive MS.
Observation:
- Two patients with secondary progressive MS (SPMS) and two healthy controls participated.
- A battery of cognitive and speech tasks was administered, including verbal fluency, digit span, and narrative speech.
- Speech tasks varied in cognitive load, from spontaneous narrative to picture description.
Findings:
- MS patients exhibited slower speech and articulation rates compared to controls.
- Increased frequency and duration of pauses were observed in MS patients across all speech tasks.
- Cognitive load significantly affected speech production more in MS patients than in controls.
Implications:
- These findings highlight the substantial impact of MS on speech production and temporal dynamics.
- Cognitive load is a critical factor influencing speech performance in individuals with MS.
- Further research is needed to understand and manage speech and language deficits in MS for improved patient care.
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