Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromosome Replication02:31

Chromosome Replication

10.5K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.5K
DNA Replication02:40

DNA Replication

58.8K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
58.8K
Replication in Prokaryotes02:35

Replication in Prokaryotes

97.2K
Overview
97.2K
Replication in Eukaryotes02:31

Replication in Eukaryotes

203.8K
Overview
203.8K
Nursing Interventions I: Taxonomy of Nursing Interventions01:03

Nursing Interventions I: Taxonomy of Nursing Interventions

3.6K
Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
3.6K
The DNA Replication Fork01:02

The DNA Replication Fork

40.6K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
40.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of remission of major depressive disorder from the alternative DSM-5 model of personality disorders.

Journal of affective disorders·2026
Same author

Parts are sometimes greater than the whole: Utilizing the WMS-IV LM Story A recognition score as an indicator of cognitive impairment.

Applied neuropsychology. Adult·2026
Same author

Dysfunctional attitudes in cognitive-behavioral therapy and antidepressant pharmacotherapy for adult depression: A systematic review and meta-analysis of individual participant data.

Journal of consulting and clinical psychology·2026
Same author

Reconstructing Psychopathology: A Data-Driven Reorganization of the Symptoms in the Diagnostic and Statistical Manual of Mental Disorders.

Clinical psychological science : a journal of the Association for Psychological Science·2025
Same author

Social anxiety in the context of the alternative DSM-5 model of personality disorder.

Journal of anxiety disorders·2025
Same author

Mania Symptoms' Complex Relations With Psychosocial Dysfunction and Personality Traits: The Role of Positive and Negative Affect.

Personality and mental health·2025

Related Experiment Video

Updated: Jan 21, 2026

Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System
10:17

Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System

Published on: April 30, 2018

8.3K

Personality profiles as potential targets for intervention: Identification and replication.

Lee Anna Clark1, Hallie Nuzum1, Jaime L Shapiro1

  • 1Department of Psychology, University of Notre Dame, Notre Dame, IN, USA.

Personality and Mental Health
|July 26, 2019
PubMed
Summary
This summary is machine-generated.

This study identified three distinct personality profiles using dimensional assessments of personality disorder (PD). These profiles offer a foundation for developing targeted, transdiagnostic treatments for individuals with personality pathology.

More Related Videos

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
10:02

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

339
Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
07:34

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

13.3K

Related Experiment Videos

Last Updated: Jan 21, 2026

Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System
10:17

Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System

Published on: April 30, 2018

8.3K
Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection
10:02

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

339
Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
07:34

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

13.3K

Area of Science:

  • Psychology
  • Psychiatry
  • Clinical Psychology

Background:

  • Current personality disorder (PD) diagnostic categories lack homogeneity.
  • An alternative dimensional model focusing on personality-functioning impairment and pathological traits offers potential for personalized treatment.
  • Transdiagnostic approaches require reliable and replicable personality dimensions.

Purpose of the Study:

  • To identify robust, replicable personality dimensions for a transdiagnostic PD treatment approach.
  • To group individuals based on these dimensions to inform tailored interventions.
  • To provide external validity for this dimensional approach in PD treatment research.

Main Methods:

  • Utilized a large battery of self-report measures to assess personality-functioning impairment and pathological traits.
  • Identified three core dimensions: self-pathology/negative affectivity (NA), interpersonal pathology/detachment, and interpersonal pathology/antagonism.
  • Replicated identified personality profiles in an additional sample using similar measures.

Main Results:

  • Identified three distinct personality profiles: high on all dimensions, elevated self-pathology/NA, and elevated interpersonal pathology without self-pathology/NA.
  • Replication confirmed the robustness of these profiles across samples.
  • Interview-based measures supported the external validity of the dimensional approach.

Conclusions:

  • The identified personality dimensions and profiles represent a significant step towards transdiagnostic PD treatment research.
  • These profiles may guide the development of treatments targeting specific issues like emotional dysregulation or interpersonal problems.
  • Further research is needed to validate these findings and expand the range of pathological personality traits included.