Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic response of peripheral chemoreflex loop to changes in end-tidal CO2.

A Berkenbosch1, J DeGoede, D S Ward

  • 1Department of Physiology and Physiological Physics, University of Leiden, The Netherlands.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 1, 1988
PubMed
Summary

The peripheral chemoreflex loop

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of the Smart Moms intervention on targeted mediators of change in child sugar-sweetened beverage intake.

Public health·2020
Same author

The physical environment in family childcare homes and children's physical activity.

Child: care, health and development·2018
Same author

A mHealth randomized controlled trial to reduce sugar-sweetened beverage intake in preschool-aged children.

Pediatric obesity·2017
Same author

Social marketing approaches to nutrition and physical activity interventions in early care and education centres: a systematic review.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Knowing when to slow down.

Anaesthesia·2017
Same author

Preventing childhood obesity in early care and education settings: lessons from two intervention studies.

Child: care, health and development·2016

Area of Science:

  • Physiology
  • Respiratory Control
  • Neuroscience

Background:

  • The peripheral chemoreflex loop plays a crucial role in regulating breathing.
  • Understanding its dynamic response to carbon dioxide is essential for respiratory control research.

Purpose of the Study:

  • To investigate the dynamic ventilatory response of the peripheral chemoreflex loop to step changes in end-tidal PCO2 (PETCO2).
  • To isolate the peripheral chemoreflex response from central chemoreflex influences using artificial brain stem perfusion.

Main Methods:

  • Studied 12 alpha-chloralose-urethan-anesthetized cats.
  • Applied isoxic step changes in PETCO2 (5-30 Torr).
  • Utilized artificial brain stem perfusion to isolate the peripheral chemoreflex loop.
  • Fitted ventilatory response data using an exponential model with time delay.

Related Experiment Videos

Main Results:

  • During normoxia, the mean time constant was 8.6 ± 7.3 s and time delay was 3.3 ± 0.9 s.
  • During hypoxia, time constant decreased to 6.0 ± 4.5 s and time delay to 2.9 ± 0.9 s.
  • Augmented breaths were observed in some runs, but their characteristics did not differ significantly in steady state.

Conclusions:

  • A single exponential with time delay adequately describes the peripheral chemoreflex loop's ventilatory response to PETCO2 step changes.
  • No evidence of a rate-sensitive component or central afterdischarge was found.