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In Vitro Synergistic Effect of Vancomycin Combined with Daptomycin Against Vancomycin-Resistant Enterococci
1Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Microbial Drug Resistance (Larchmont, N.Y.)
|July 26, 2019
Summary
Vancomycin combined with daptomycin shows 100% synergy against vancomycin-resistant enterococci (VRE) infections in vitro. This combination therapy presents a promising new option for treating challenging VRE infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- The incidence of vancomycin-resistant enterococci (VRE) infections is increasing globally.
- Treatment options for VRE infections remain limited, necessitating novel therapeutic strategies.
Purpose of the Study:
- To investigate the in vitro synergistic activity of vancomycin and daptomycin against VRE strains.
- To evaluate the efficacy of this antibiotic combination in combating multidrug-resistant pathogens.
Main Methods:
- Minimum inhibitory concentrations (MICs) were determined using broth microdilution assays.
- Synergistic effects were assessed via broth microcheckerboard and time-kill curve analyses.
- Viable bacterial counts were monitored over 72-hour intervals.
Main Results:
- A 100% synergistic effect was observed for the vancomycin-daptomycin combination using the broth microcheckerboard method.
- Time-kill assays confirmed synergistic activity at both 1x MIC and 0.5x MIC concentrations.
- The combination demonstrated potent in vitro activity against all tested VRE strains.
Conclusions:
- The combination of vancomycin and daptomycin exhibits significant in vitro synergy against VRE.
- This combination therapy holds potential as an effective treatment for VRE-associated infections.
- Further clinical investigation is warranted to confirm efficacy in patients.
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