A 3-year Randomized Clinical Trial of MiSight Lenses for Myopia Control

Area of Science:

• Ophthalmology
• Optometry
• Pediatric Eye Care

Background:

• Myopia, or nearsightedness, is a growing public health concern, particularly in children.
• Effective myopia control strategies are crucial to prevent high myopia and associated ocular complications.
• Daily disposable contact lenses offer a convenient and potentially effective option for myopia management.

Purpose of the Study:

• To evaluate the efficacy of the MiSight daily disposable soft contact lens in slowing the progression of juvenile-onset myopia.
• To quantify the impact of MiSight lenses on refractive error and axial length changes in children.

Main Methods:

• A 3-year, randomized, double-masked clinical trial involving myopic children aged 8-12 years with no prior contact lens experience.
• Participants were randomized to wear either MiSight 1-day (test) or Proclear 1-day (control) daily disposable soft contact lenses.
• Primary outcome measures included changes in cycloplegic spherical equivalent refraction and axial length.

Main Results:

• The MiSight lens group showed a 59% less change in spherical equivalent refraction compared to the control group (-0.51 D vs. -1.24 D).
• Mean change in axial length was 52% less in the MiSight group (0.30 mm vs. 0.62 mm).
• No serious ocular adverse events were reported; four asymptomatic corneal infiltrative events occurred.

Conclusions:

• MiSight daily disposable soft contact lenses are effective in slowing myopia progression in children.
• The lenses demonstrated a significant reduction in both refractive error and axial length elongation.
• This study supports the use of MiSight lenses as a viable myopia control option.