Related Experiment Video
Updated: Jan 21, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
2.2K
IGSF1: A novel oncogene regulates the thyroid cancer progression
Yaoyao Guan1, Yinghao Wang1, Adheesh Bhandari1
1Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Cell Biochemistry and Function
|July 26, 2019
Summary
Immunoglobulin superfamily member 1 (IGSF1) is upregulated in thyroid cancer, promoting tumor growth and metastasis. Silencing IGSF1 inhibits proliferation and metastasis while enhancing apoptosis in thyroid cancer cells.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Thyroid cancer incidence is rising globally.
- Genetic diagnosis is crucial for thyroid cancer management.
- Immunoglobulin superfamily member 1 (IGSF1) regulates thyroid hormone but its role in thyroid cancer is unknown.
Purpose of the Study:
- To investigate the correlation between IGSF1 expression and thyroid cancer.
- To elucidate the function of IGSF1 in thyroid cancer progression.
Main Methods:
- Analysis of IGSF1 expression in 55 thyroid cancer tissue pairs using real-time PCR.
- Utilizing The Cancer Genome Atlas (TCGA) data.
- Silencing IGSF1 in thyroid cancer cell lines (KTC-1, BCPAP) via small interfering RNA.
- Assessing cell proliferation, migration, invasion, and apoptosis.
Main Results:
- IGSF1 was significantly upregulated in thyroid cancer tissues compared to normal tissues (P < .0001).
- TCGA data also showed elevated IGSF1 levels in thyroid cancer (P < .0001).
- Downregulating IGSF1 inhibited proliferation and metastasis, and promoted apoptosis in thyroid cancer cells.
- Inhibited IGSF1 expression led to decreased levels of N-cadherin, vimentin, and EZH2, markers associated with metastasis.
Conclusions:
- IGSF1 is upregulated in thyroid cancer and plays a significant role in tumor growth, metastasis, and apoptosis.
- IGSF1 expression levels correlate with the aggressive phenotype of thyroid cancer cells.
- Targeting IGSF1 may offer a potential therapeutic strategy for thyroid cancer.
Related Concept Videos
01:33Cancer-Critical Genes I: Proto-oncogenes
11.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.2K
01:20Synthesis and Regulation of Thyroid Hormones
7.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.3K
03:03mTOR Signaling and Cancer Progression
4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.7K
01:23The Thyroid Gland
6.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.8K
01:45Positive Regulator Molecules
134.6K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
134.6K
01:46Epigenetic Regulation
33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K