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Updated: Jan 21, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
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Nicotine absorption during electronic cigarette use among regular users.

Jessica M Yingst1, Jonathan Foulds1, Susan Veldheer1

  • 1Department of Public Health Sciences, Tobacco Center of Regulatory Science, Pennsylvania State University, College of Medicine, Hershey, PA, United States of America.

Plos One
|July 26, 2019
PubMed
Summary
This summary is machine-generated.

Advanced e-cigarettes deliver more nicotine than first-generation devices but less than traditional cigarettes. Both e-cigarette types reduced withdrawal symptoms and cravings, with no reported side effects.

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Area of Science:

  • Tobacco Harm Reduction
  • Nicotine Pharmacokinetics
  • Electronic Nicotine Delivery Systems (ENDS)

Background:

  • Electronic cigarette (e-cig) nicotine delivery is crucial for combustible cigarette replacement.
  • Two e-cig classes and combustible cigarettes were compared for nicotine delivery and user experience.
  • Understanding nicotine absorption from e-cigs is vital for smoking cessation research.

Purpose of the Study:

  • To compare nicotine delivery and subjective effects between two e-cigarette types and combustible cigarettes.
  • To evaluate the impact of e-cigarette use on withdrawal symptoms and craving.
  • To inform the use of e-cigarettes in smoking cessation strategies.

Main Methods:

  • 14 e-cigarette users vaped their devices for 10 minutes, with blood nicotine levels measured over 15 minutes.
  • Participants rated withdrawal and side effects before and after vaping.
  • E-cigarettes were categorized as first-generation or advanced; 10 cigarette smokers underwent a similar protocol.

Main Results:

  • Advanced e-cigarettes yielded significantly higher peak nicotine concentrations (Cmax) and nicotine boost compared to first-generation devices.
  • E-cigarette users reported significant reductions in withdrawal and craving, with no significant differences between device types.
  • Combustible cigarettes resulted in higher Cmax and nicotine boost than both e-cigarette types.

Conclusions:

  • Advanced e-cigarettes provide greater nicotine delivery than first-generation devices but less than combustible cigarettes.
  • E-cigarette use effectively reduced withdrawal and craving without adverse effects.
  • Variability in nicotine absorption across e-cigarette devices necessitates careful consideration in smoking cessation studies.