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Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice
Published on: September 26, 2019
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Emphysema phenotypes and lung cancer risk.
Jessica González1, Claudia I Henschke2, David F Yankelevitz2
1Pulmonary Service, Clínica Universidad de Navarra, Pamplona, Spain.
Plos One
|July 26, 2019
Summary
Emphysema subtypes significantly impact lung cancer risk. The centrilobular type shows the highest risk, while paraseptal emphysema may decrease it, highlighting the importance of visual emphysema assessment in lung cancer prediction.
Area of Science:
- Pulmonology
- Oncology
- Radiology
Background:
- Emphysema and airflow obstruction are known risk factors for lung cancer.
- However, the specific risks associated with different emphysema subtypes remain unclear.
- Visual assessment offers a method to evaluate emphysema phenotypes.
Purpose of the Study:
- To investigate the association between lung cancer and various emphysema subtypes.
- To determine if emphysema type and severity influence lung cancer risk.
- To utilize visual assessment for risk stratification.
Main Methods:
- A case-control study matched 72 lung cancer patients with 3 controls each from a lung cancer screening cohort.
- Participants underwent visual assessment of emphysema and spirometry.
- Logistic regression and interaction models analyzed the relationship between emphysema subtypes and lung cancer.
Main Results:
- Both airflow obstruction (OR=2.8) and visual emphysema (OR=5.9) were linked to increased lung cancer risk.
- Higher emphysema severity (OR=12.6) and the centrilobular subtype (OR=34.3) showed significantly greater risk.
- Paraseptal emphysema appeared to reduce lung cancer risk (OR=4.0), especially when not present alone (OR=0.7).
Conclusions:
- Visual emphysema scoring is a valuable tool for predicting lung cancer risk.
- The centrilobular emphysema phenotype is associated with the most substantial increase in lung cancer risk.
- Understanding emphysema subtypes can refine lung cancer risk assessment.
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